Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.66 |
| ▸ | KDR | P35968 | 6/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | PLK4 | O00444 | 2/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | LCK | P06239 | 2/20 | 0.63 |
| ▸ | FYN | P06241 | 2/20 | 0.63 |
| ▸ | LYN | P07948 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.63 |
| ▸ | AXL | P30530 | 2/20 | 0.63 |
| ▸ | FRK | P42685 | 2/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.63 |
| ▸ | BLK | P51451 | 2/20 | 0.63 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568327 | 0.89 | RAF1 (0.80) | RAF1KDRGSK3BPLK4AURKA | |
| SCHEMBL3408499 | 0.88 | RAF1 (0.83) | RAF1KDRGSK3BPLK4AURKA | |
| SCHEMBL29793192 | 0.88 | RAF1 (0.83) | RAF1KDRGSK3BPLK4AURKA | |
| SCHEMBL5568335 | 0.85 | KDR (0.67) | RAF1KDRGSK3BPLK4AURKA | |
| SCHEMBL5621314 | 0.85 | RAF1 (0.64) | RAF1KDRGSK3BPLK4AURKA | |
| Formamide SCHEMBL28340615 | 0.84 | RAF1 (0.79) | RAF1KDRGSK3BPLK4AURKA | |
| SCHEMBL22473675 | 0.83 | KDR (0.80) | RAF1KDRPLK4AURKAMAPK13 | |
| SCHEMBL12260935 | 0.81 | RAF1 (0.69) | RAF1KDRGSK3BPLK4AURKA | |
| SCHEMBL3411566 | 0.81 | RET (0.81) | RAF1KDRGSK3BPLK4AURKA | |
| SCHEMBL28948534 | 0.80 | RAF1 (0.83) | RAF1KDRGSK3BPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007519653-A | — | — | 2007-07-19 | — | — | JP | claimed |
| EP-1730111-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005075425-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-08-18 | — | — | WO | claimed |