Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.59 |
| ▸ | BRAF | P15056 | 13/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | ARAF | P10398 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723639 | 0.92 | LCK (0.54) | LCKBRAFRAF1ARAF | |
| SCHEMBL5622001 | 0.90 | LCK (0.69) | LCKBRAFRAF1KITKDR | |
| SCHEMBL374492 | 0.89 | LCK (0.70) | LCKBRAFRAF1KITKDR | |
| SCHEMBL4724854 | 0.88 | BRAF (0.67) | LCKBRAFRAF1ARAF | |
| SCHEMBL4724615 | 0.88 | BRAF (0.66) | LCKBRAFRAF1ARAFKDR | |
| SCHEMBL5622922 | 0.87 | LCK (0.58) | LCKBRAFRAF1ARAFKDR | |
| SCHEMBL14606518 | 0.85 | BRAF (0.54) | LCKBRAFRAF1ARAF | |
| SCHEMBL5622702 | 0.84 | LCK (0.57) | LCKBRAFRAF1ARAFKDR | |
| SCHEMBL5622575 | 0.84 | BRAF (0.54) | LCKBRAFRAF1ARAF | |
| SCHEMBL14572528 | 0.84 | BRAF (0.51) | LCKBRAFRAF1ARAFKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070049592-A1 | Bis-aryl urea compounds and methods of use | AMGEN INC. | 2007-03-01 | — | — | US | claimed |
| US-20070049592-A1 | Bis-aryl urea compounds and methods of use | AMGEN INC. | 2007-03-01 | — | — | US | disclosed |
| WO-2007024754-A1 | BIS-ARYL UREA COMPOUNDS FOR THE TREATMENT OF PROTEIN KINASE-MEDIATED DISEAES | AMGEN INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| US-20070049592-A1 | Bis-aryl urea compounds and methods of use | AMGEN INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049592-A1 | Bis-aryl urea compounds and methods of use | AMGEN INC. | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049592-A1 | Bis-aryl urea compounds and methods of use | TIE1, KDR, BDKRB2 | LCK 376/4885BRAF 254/4885RAF1 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.