Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542724 | 0.82 | ALDH1A1 (0.55) | KMT2AMEN1TDP1ALDH1A1TSHR | |
| SCHEMBL2554998 | 0.81 | KMT2A (0.57) | KMT2AMEN1TDP1ALDH1A1CYP2C19 | |
| SCHEMBL31562446 | 0.81 | KMT2A (0.57) | KMT2AMEN1TDP1ALDH1A1CYP2C19 | |
| SCHEMBL29954117 | 0.80 | KMT2A (0.48) | KMT2AMEN1TDP1ALDH1A1TP53 | |
| SCHEMBL2291002 | 0.80 | ALDH1A1 (0.49) | KMT2AMEN1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20541205 | 0.79 | ALDH1A1 (0.52) | KMT2AMEN1TDP1ALDH1A1CYP1A2 | |
| SCHEMBL29084863 | 0.79 | ALDH1A1 (0.52) | KMT2AMEN1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL15329848 | 0.79 | KMT2A (0.47) | KMT2AMEN1TDP1ALDH1A1TP53 | |
| SCHEMBL19816980 | 0.78 | ALDH1A1 (0.50) | KMT2AMEN1TDP1ALDH1A1CYP1A2 | |
| SCHEMBL4611512 | 0.78 | NPC1 (0.57) | KMT2AMEN1TDP1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226945-B2 | Estrogen receptor-β ligands | ASTRAZENECA AB (SE) | 2007-06-05 | — | — | US | disclosed |
| US-20050043350-A9 | Estrogen Receptor-beta ligands | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | US | disclosed |
| US-20040039015-A1 | Estrogen Receptor-beta ligands | BARLAAM BERNARD (FR) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043350-A9 | Estrogen Receptor-beta ligands | ESR2, GPER1, ESR1 | KMT2A 604/4885MEN1 3611/4885TDP1 4753/4885 |
| US-20040039015-A1 | Estrogen Receptor-beta ligands | ESR2, GPER1, ESRRG | KMT2A 2460/4885MEN1 3185/4885TDP1 4588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.