Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 15/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5117430 | 0.92 | TAS2R14 (0.62) | TAS2R14MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL5117441 | 0.92 | TAS2R14 (0.62) | TAS2R14MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL5122191 | 0.89 | TAS2R14 (0.53) | TAS2R14MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL5116607 | 0.89 | TAS2R14 (0.64) | TAS2R14MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL5116620 | 0.89 | TAS2R14 (0.64) | TAS2R14MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL5122060 | 0.87 | KDM4E (0.53) | TAS2R14PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5122055 | 0.87 | KDM4E (0.53) | TAS2R14PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5128796 | 0.85 | PSEN1 (0.54) | TAS2R14MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL5128798 | 0.85 | PSEN1 (0.54) | TAS2R14MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL5124198 | 0.84 | PSEN1 (0.54) | TAS2R14MEN1KMT2APSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163942-B2 | Sulfonamide compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2007-01-16 | — | — | US | disclosed |
| US-20050222254-A1 | Sulfonamide compounds for the treatment of neurodegenerative disorders | PFIZER INC | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222254-A1 | Sulfonamide compounds for the treatment of neurodegenerative disorders | PSEN1, APP, PSEN2 | TAS2R14 1257/4885MEN1 751/4885KMT2A 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.