Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061416 | 0.79 | RPS6KA5 (0.43) | SMN1; SMN2MAPTALDH1A1RPS6KB1ROCK1 | |
| SCHEMBL3068284 | 0.79 | RAB9A (0.39) | SMN1; SMN2POLBMAPTALDH1A1KMT2A | |
| SCHEMBL3065868 | 0.78 | USP2 (0.43) | POLBMAPTMEN1KMT2ANPC1 | |
| SCHEMBL3060407 | 0.78 | RPS6KA5 (0.37) | SMN1; SMN2POLBMAPTALDH1A1MEN1 | |
| SCHEMBL3067378 | 0.77 | MAPT (0.36) | MAPTMEN1KMT2ANPC1TP53 | |
| SCHEMBL3061362 | 0.75 | MAPT (0.43) | MAPTKCNH2NPC1TP53CASP1 | |
| SCHEMBL3049560 | 0.75 | TP53 (0.36) | SMN1; SMN2MAPTNPC1TP53CASP1 | |
| SCHEMBL3059564 | 0.75 | MAPT (0.36) | SMN1; SMN2MAPTALDH1A1NPC1TP53 | |
| SCHEMBL3068443 | 0.74 | HTT (0.40) | POLBALDH1A1LMNA | |
| SCHEMBL3072695 | 0.73 | MAPT (0.40) | SMN1; SMN2MAPTKCNH2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300945-B2 | Benzimidazole and pyridylimidazole derivatives | NEUROGEN CORPORATION (US) | 2007-11-27 | — | — | US | claimed |