Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.52 |
| ▸ | RARB | P10826 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5625817 | 1.00 | HTT (0.64) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL8679407 | 0.93 | HTT (0.72) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL224332 | 0.93 | HTT (0.72) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL9108115 | 0.93 | HTT (0.72) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL1531836 | 0.93 | HTT (0.72) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL2887975 | 0.93 | HTT (0.72) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL8744843 | 0.93 | HTT (0.72) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL9471681 | 0.93 | HTT (0.72) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1178447 | 0.92 | HTT (0.70) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL13697348 | 0.92 | TSHR (0.59) | HTTALDH1A1TSHRTHRBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7311948-B2 | Isosorbide derivatives | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2007-12-25 | — | — | US | disclosed |
| US-20040232383-A1 | Isosorbide derivatives | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2004-11-25 | — | — | US | disclosed |
| EP-1432716-A1 | ISOSORBIDE DERIVATIVES | Koninklijke Philips Electronics N.V. (NL) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027119-A1 | ISOSORBIDE DERIVATIVES | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040232383-A1 | Isosorbide derivatives | CRY2, INF2, IKZF1 | HTT 2291/4885POLB 474/4885APEX1 1624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.