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Sugi Predict / Targets / CRY2

CRY2

Cryptochrome-2 · Q49AN0 · CRY2 on Sugi Atlas →

5,433 patent compounds predicted against CRY2, 2,037 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL9004363 SCHEMBL9004363 0.47 18/20
SCHEMBL3922170 SCHEMBL3922170 0.34 16/20
SCHEMBL11709963 SCHEMBL11709963 0.52 15/20
SCHEMBL734385 SCHEMBL734385 0.43 13/20
SCHEMBL2151617 SCHEMBL2151617 0.42 12/20
SCHEMBL8134208 SCHEMBL8134208 0.49 10/20
SCHEMBL8488753 SCHEMBL8488753 0.51 9/20
SCHEMBL607629 SCHEMBL607629 0.46 9/20
SCHEMBL8143242 SCHEMBL8143242 0.45 9/20
SCHEMBL5797737 SCHEMBL5797737 0.44 9/20
SCHEMBL6738280 SCHEMBL6738280 0.36 9/20
SCHEMBL14280689 SCHEMBL14280689 0.35 9/20
SCHEMBL6693467 SCHEMBL6693467 0.33 9/20
SCHEMBL1353734 SCHEMBL1353734 0.48 8/20
SCHEMBL2151350 SCHEMBL2151350 0.41 8/20
SCHEMBL14280687 SCHEMBL14280687 0.41 8/20
SCHEMBL8230645 SCHEMBL8230645 0.32 8/20
SCHEMBL8489489 SCHEMBL8489489 0.60 7/20
SCHEMBL6734108 SCHEMBL6734108 0.51 7/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL7461051) 0.50 7/20

Clinical trials — most relevant to CRY2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar PHASE2/PHASE3UNKNOWN
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers PHASE3COMPLETED
Exogenous Melatonin in Intensive Care Unit Chronodisruption PHASE3UNKNOWN
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy PHASE3RECRUITING
Biological Clock Dysfunction in Optic Nerve Hypoplasia EARLY_PHASE1COMPLETED
Circadian Rhythm in Critical Illness nanCOMPLETED
PER3 Clock Gene Polymorphism, Clock Gene Expression and Delirium in the Intensive Care Unit. nanWITHDRAWN
Restoring Molecular Circadian Rhythm nanSUSPENDED
Circadian Rhythms and Sleep in Familial DSPS and ASPS nanCOMPLETED
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption nanNOT_YET_RECRUITING
Functionality of Endogenous Biological Clock in Sepsis nanUNKNOWN
Meal Timing, Genetics and Weight Loss nanRECRUITING
Evaluation of Circadian OS Technology on Melatonin Suppression nanCOMPLETED
Light Therapy in Cardiopulmonary Bypass Surgery nanWITHDRAWN
Melatonin Receptor Agonist and Peripheral Biological Markers nanCOMPLETED
Identification of Novel Circadian Biomarkers nanCOMPLETED
Light Sensitization Study nanCOMPLETED
Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism nanCOMPLETED
Study of Circadian Clock Properties in Healthy Subjects, Obese and Type 2 Diabetic Patients. nanUNKNOWN
The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood nanUNKNOWN
Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder nanCOMPLETED
The Role of Circadian Clock Proteins in Innate and Adaptive Immunity nanRECRUITING
The Clinical Research on the Relationship Between Depression and Gut Microbiota in TBI Patients nanUNKNOWN
The Effect of Melatonin on Sleep and Ventilatory Control in Obstructive Sleep Apnea nanCOMPLETED
Circadian Rhythm Disruption Effects on Smoke Inhalation nanCOMPLETED
Metabolic Investigation, Physical Performance, Physical Training At Different Times of the Day in Obese Women nanACTIVE_NOT_RECRUITING
Effect of Liraglutide on Clock Genes nanUNKNOWN
Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms nanACTIVE_NOT_RECRUITING
Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, SIDERALE nanRECRUITING
The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation. nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a CRY2 binder may also engage these)

ProteinNameSimilarity
Q9R194 — 1.000 Q9R194 →
Q923I8 — 1.000 Q923I8 →
CRY1 Cryptochrome-1 0.998 landscape →
Q32Q86 — 0.997 Q32Q86 →
Q8QG61 — 0.997 Q8QG61 →
Q8WP19 — 0.997 Q8WP19 →
Q17DK5 — 0.996 Q17DK5 →
Q70AD6 — 0.995 Q70AD6 →
Q6ZZY0 — 0.995 Q6ZZY0 →
Q5IZC5 — 0.994 Q5IZC5 →
O48652 — 0.992 O48652 →
P97784 — 0.992 P97784 →
Q8QG60 — 0.991 Q8QG60 →
Q7PYI7 — 0.988 Q7PYI7 →
Q96524 — 0.987 Q96524 →
O77059 — 0.986 O77059 →
Q0E2Y1 — 0.984 Q0E2Y1 →
E9F0S1 — 0.984 E9F0S1 →
Q28811 — 0.983 Q28811 →
KDM5D Lysine-specific demethylase 5D 0.982 landscape →
P41230 — 0.981 P41230 →
Q293P8 — 0.981 Q293P8 →
Q9D2E2 — 0.981 Q9D2E2 →
Q5XUN4 — 0.981 Q5XUN4 →
Q5RAR6 — 0.981 Q5RAR6 →
Q80Y84 — 0.981 Q80Y84 →
OGA Protein O-GlcNAcase 0.980 landscape →
Q2T9L8 — 0.980 Q2T9L8 →
Q08BC6 — 0.980 Q08BC6 →
KDM1A Lysine-specific histone demethylase 1A 0.980 landscape →