Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 3/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12783277 | 0.71 | PTAFR (0.48) | PTAFREED | |
| SCHEMBL20368824 | 0.70 | CFTR (0.32) | CFTRPTAFREEDABCB11ALDH1A1 | |
| SCHEMBL7868294 | 0.69 | KDM4E (0.36) | CFTRPTAFREEDALDH1A1CYP2D6 | |
| SCHEMBL10375401 | 0.69 | CFTR (0.32) | CFTRPTAFREED | |
| SCHEMBL10028949 | 0.69 | CFTR (0.32) | CFTRPTAFREED | |
| SCHEMBL3109000 | 0.69 | PTAFR (0.42) | PTAFREEDALDH1A1TP53CYP2C19 | |
| SCHEMBL14520555 | 0.67 | SETD7 (0.39) | ABCB11ALDH1A1TP53CYP1A2CHRM2 | |
| SCHEMBL8003376 | 0.66 | — | — | |
| SCHEMBL10642347 | 0.64 | ALDH1A1 (0.33) | ABCB11ALDH1A1TP53CYP1A2CHRM2 | |
| SCHEMBL10375396 | 0.63 | PTAFR (0.34) | CFTRPTAFREEDABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307088-B2 | Substituted anthranilic amide derivatives and methods of use | AMGEN INC. (US) | 2007-12-11 | — | — | US | disclosed |