Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4813147 | 0.83 | TACR1 (0.53) | TACR1SLC6A4CCR2SLC6A3SLC6A2 | |
| SCHEMBL27607905 | 0.81 | TACR1 (0.50) | TACR1SLC6A4CCR2SLC6A3SLC6A2 | |
| SCHEMBL4631291 | 0.81 | TACR1 (0.56) | TACR1SLC6A4KCNH2 | |
| SCHEMBL4816350 | 0.80 | TACR1 (0.48) | TACR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL6266690 | 0.79 | SLC6A4 (0.51) | TACR1SLC6A4CCR2SLC6A3SLC6A2 | |
| Hydrochloric Acid SCHEMBL27626949 | 0.78 | CCR2 (0.46) | TACR1SLC6A4CCR2SLC6A3SLC6A2 | |
| SCHEMBL8886072 | 0.77 | CCR2 (0.45) | TACR1SLC6A4CCR2SLC6A3SLC6A2 | |
| SCHEMBL2811089 | 0.77 | TACR1 (0.53) | TACR1SLC6A4CCR2SLC6A3SLC6A2 | |
| SCHEMBL12585395 | 0.77 | SLC6A4 (0.74) | TACR1SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL4848259 | 0.77 | SLC6A4 (0.52) | TACR1SLC6A4CCR2SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294628-B2 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-11-13 | — | — | US | disclosed |