Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | LPO | P22079 | 2/20 | 0.37 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617201 | 0.87 | PRKCI (0.50) | ALDH1A1GAAMAPK14PRKCINOTUM | |
| SCHEMBL2003464 | 0.83 | NR1H2 (0.45) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL423280 | 0.82 | KDM4E (0.42) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL397539 | 0.81 | NOTUM (0.58) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL11962998 | 0.81 | NOTUM (0.58) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL12480601 | 0.81 | IRAK4 (0.40) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL13726436 | 0.81 | HTR6 (0.39) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL15232029 | 0.79 | MAPK11 (0.48) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL15232028 | 0.79 | KDM4E (0.53) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL27729357 | 0.79 | TSHR (0.47) | ALDH1A1KDM4ETP53HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070082912-A1 | Pyrrole compounds for the treatment of prostaglandine mediated diseases | GLAXO GROUP LIMITED (GB) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082912-A1 | Pyrrole compounds for the treatment of prostaglandine mediated diseases | PTGER1, PTGDR, PTGIR | ALDH1A1 1403/4885KDM4E 1761/4885TP53 4086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.