Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14442989 | 0.95 | IDO1 (0.36) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL5631316 | 0.91 | SMN1; SMN2 (0.34) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5632016 | 0.90 | SMN1; SMN2 (0.35) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL5630925 | 0.89 | SMN1; SMN2 (0.35) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4981733 | 0.88 | MAPT (0.46) | SMN1; SMN2IDO1MEN1KMT2AMAPT | |
| Trifluoroacetic Acid SCHEMBL5633383 | 0.88 | MAPT (0.46) | SMN1; SMN2IDO1MEN1KMT2AMAPT | |
| Trifluoroacetic Acid SCHEMBL5632104 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14442998 | 0.85 | MEN1 (0.34) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL5632789 | 0.84 | IDO1 (0.37) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5630673 | 0.84 | MEN1 (0.39) | SMN1; SMN2IDO1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185165-A1 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-09 | — | — | US | claimed |
| US-20070185165-A1 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185165-A1 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, HNMT | SMN1; SMN2 3175/4885IDO1 1/4885CYP1A2 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.