Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 20/20 | 0.72 |
| ▸ | TDO2 | P48775 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972399 | 0.90 | IDO1 (0.75) | IDO1TDO2CYP3A4CYP2C9IDO2 | |
| SCHEMBL5631820 | 0.90 | IDO1 (0.69) | IDO1TDO2 | |
| SCHEMBL5630958 | 0.89 | IDO1 (0.61) | IDO1TDO2 | |
| SCHEMBL4983001 | 0.89 | IDO1 (0.71) | IDO1TDO2CYP3A4CYP2C9IDO2 | |
| SCHEMBL5631283 | 0.89 | IDO1 (0.73) | IDO1TDO2CYP3A4CYP2C9IDO2 | |
| SCHEMBL5630721 | 0.88 | IDO1 (0.60) | IDO1TDO2 | |
| SCHEMBL4980100 | 0.88 | IDO1 (0.60) | IDO1TDO2 | |
| SCHEMBL5630190 | 0.87 | IDO1 (0.58) | IDO1TDO2 | |
| SCHEMBL5631925 | 0.87 | IDO1 (0.59) | IDO1TDO2 | |
| SCHEMBL4974805 | 0.87 | IDO1 (0.57) | IDO1TDO2CYP3A4CYP2C9IDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951536-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2015-02-10 | — | — | US | claimed |
| US-20130177590-A1 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2013-07-11 | — | — | US | claimed |
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |
| US-20070185165-A1 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION | 2007-08-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130177590-A1 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, HNMT | IDO1 1/4885TDO2 13/4885CYP3A4 476/4885 |
| US-20070185165-A1 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, HNMT | IDO1 1/4885TDO2 13/4885CYP3A4 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.