Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.55 |
| ▸ | CACNB1 | Q02641 | 6/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5633709 | 0.89 | CYP3A4 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1CHPGD | |
| SCHEMBL5634371 | 0.87 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1GCNR1 | |
| SCHEMBL5634401 | 0.84 | CACNA2D1 (0.56) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL5634382 | 0.83 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CHPGD | |
| SCHEMBL5634872 | 0.83 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CHPGD | |
| SCHEMBL5634736 | 0.80 | CACNA2D1 (0.56) | CACNA2D1CACNA1BCACNB1CACNA1CHPGD | |
| SCHEMBL4475771 | 0.77 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL4477780 | 0.77 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL4475768 | 0.77 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1GCACNA1C | |
| SCHEMBL5634993 | 0.77 | KCNH2 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1CBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244758-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-07-17 | — | — | US | claimed |
| CN-1816332-A | 3-aminomethyl-pyrrolidines as N-type calcium channel blockers | NEUROMED TECH INC (CA) | 2006-08-09 | — | — | CN | claimed |
| US-20050014748-A1 | N-type calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-01-20 | — | — | US | claimed |
| US-7244758-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014748-A1 | N-type calcium channel blockers | CACNA1B, CACNA1C, CACNA1I | CACNA2D1 30/4885CACNA1B 1/4885CACNB1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.