Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.49 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.49 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634371 | 0.93 | CACNA2D1 (0.54) | CYP3A4CYP2D6CYP2C9PKMHPGD | |
| SCHEMBL5634872 | 0.93 | CACNA2D1 (0.54) | CYP3A4CYP2D6CYP2C9PKMHPGD | |
| SCHEMBL5634382 | 0.93 | CACNA2D1 (0.54) | CYP3A4CYP2D6CYP2C9PKMHPGD | |
| SCHEMBL5634736 | 0.90 | CACNA2D1 (0.56) | CYP3A4CYP2D6CYP2C9PKMHPGD | |
| SCHEMBL5634401 | 0.90 | CACNA2D1 (0.56) | CYP3A4CYP2D6CYP2C9PKMHPGD | |
| SCHEMBL5633428 | 0.89 | CACNA2D1 (0.55) | CYP3A4CYP2D6CYP2C9PKMHPGD | |
| SCHEMBL5634993 | 0.86 | KCNH2 (0.53) | CACNA2D1CACNB1CACNA1CCACNA1ABCHE | |
| SCHEMBL5634490 | 0.83 | CACNA2D1 (0.52) | CACNA2D1CACNB1CACNA1CCACNA1BMEN1 | |
| SCHEMBL5633417 | 0.81 | PTGIR (0.55) | CACNA2D1CACNB1CACNA1CCACNA1BMEN1 | |
| SCHEMBL8298777 | 0.79 | CKS1B (0.51) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244758-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-07-17 | — | — | US | claimed |
| CN-1816332-A | 3-aminomethyl-pyrrolidines as N-type calcium channel blockers | NEUROMED TECH INC (CA) | 2006-08-09 | — | — | CN | claimed |
| US-20050014748-A1 | N-type calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-01-20 | — | — | US | claimed |
| US-7244758-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-07-17 | — | — | US | disclosed |
| US-7244758-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-07-17 | — | — | US | disclosed |
| US-7244758-B2 | N-type calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-07-17 | — | — | US | disclosed |
| CN-1816332-A | 3-aminomethyl-pyrrolidines as N-type calcium channel blockers | NEUROMED TECH INC (CA) | 2006-08-09 | — | — | CN | disclosed |
| US-20050014748-A1 | N-type calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-01-20 | — | — | US | disclosed |
| WO-2004105750-A1 | 3-AMINOMETHYL-PYRROLIDINES AS N-TYPE CALCIUM CHANNEL BLOCKERS | NEUROMED TECHNOLOGIES, INC. (CA) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014748-A1 | N-type calcium channel blockers | CACNA1B, CACNA1C, CACNA1I | CYP3A4 2190/4885CYP2D6 3363/4885CYP2C9 3218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.