Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145968 | 0.81 | KDM4E (0.64) | KDM4ENPC1RAB9AMAPTGLA | |
| Hydrochloric Acid SCHEMBL5552749 | 0.79 | KDM4E (0.62) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL266497 | 0.77 | KDM4E (0.64) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL6850546 | 0.77 | KDM4E (0.64) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL1314775 | 0.77 | KDM4E (0.64) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL5017666 | 0.77 | ASIC3 (0.42) | KDM4EMAPTL3MBTL1ALDH1A1AGXT | |
| SCHEMBL3069800 | 0.75 | KDM4E (1.00) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL10162362 | 0.75 | KDM4E (0.66) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL6850784 | 0.75 | KDM4E (0.60) | KDM4ENPC1RAB9AMAPTGLA | |
| SCHEMBL27968491 | 0.75 | KDM4E (0.60) | KDM4ENPC1RAB9AMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140135485-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-20120035352-A1 | 6-11 Bicyclic Ketolide Derivatives | OR YAT SUN (US) | 2012-02-09 | — | — | US | disclosed |
| EP-1506214-B1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARM INC (US) | 2010-01-20 | — | — | EP | disclosed |
| US-20090324577-A1 | 6-11 Bicyclic Ketolide Derivatives | OR YAT SUN | 2009-12-31 | — | — | US | disclosed |
| US-20070244160-A1 | 6-11 Bicyclic Ketolide Derivatives | OR YAT SUN | 2007-10-18 | — | — | US | disclosed |
| US-7273853-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2007-09-25 | — | — | US | disclosed |
| US-7189704-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7064110-B2 | 6-11 bicycle ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2006-06-20 | — | — | US | disclosed |
| US-20050282758-A1 | 6-11 Bicyclic ketolide derivatives | NIU DEQIANG | 2005-12-22 | — | — | US | disclosed |
| US-20050159370-A1 | 6-11 Bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2005-07-21 | — | — | US | disclosed |
| WO-2005061526-A1 | 6-11 BICYCLIC KETOLIDE DRIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061525-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| US-6878691-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2005-04-12 | — | — | US | disclosed |
| EP-1506214-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | Enanta Pharmaceuticals, Inc. (US) | 2005-02-16 | — | — | EP | disclosed |
| US-20040157787-A1 | 6-11 Bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. | 2004-08-12 | — | — | US | disclosed |
| WO-2003097659-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135485-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | AKR1C2, AKR1C3, AKR1C1 | KDM4E 56/4885NPC1 387/4885RAB9A 2564/4885 |
| US-20120035352-A1 | 6-11 Bicyclic Ketolide Derivatives | AKR1C2, AKR1C3, AKR1C1 | KDM4E 56/4885NPC1 387/4885RAB9A 2564/4885 |
| US-20050282758-A1 | 6-11 Bicyclic ketolide derivatives | AKR1C2, AKR1C3, AKR1C1 | KDM4E 56/4885NPC1 387/4885RAB9A 2564/4885 |
| US-20070244160-A1 | 6-11 Bicyclic Ketolide Derivatives | AKR1C2, AKR1C3, AKR1C1 | KDM4E 56/4885NPC1 387/4885RAB9A 2564/4885 |
| US-20090324577-A1 | 6-11 Bicyclic Ketolide Derivatives | AKR1C2, AKR1C3, AKR1C1 | KDM4E 56/4885NPC1 387/4885RAB9A 2564/4885 |
| US-20040157787-A1 | 6-11 Bicyclic ketolide derivatives | AKR1C2, AKR1C3, AKR1C1 | KDM4E 57/4885NPC1 377/4885RAB9A 2499/4885 |
| US-20050159370-A1 | 6-11 Bicyclic ketolide derivatives | AKR1C2, AKR1C3, AKR1C1 | KDM4E 56/4885NPC1 387/4885RAB9A 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.