Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.65 |
| ▸ | CASP1 | P29466 | 3/20 | 0.65 |
| ▸ | CASP7 | P55210 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 11/20 | 0.53 |
| ▸ | CCND1 | P24385 | 10/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5632985 | 0.87 | CDK4 (0.61) | CYP1A2CLK4CASP1CASP7CYP3A4 | |
| SCHEMBL5634938 | 0.86 | CDK4 (0.60) | CYP1A2CLK4CASP1CASP7CYP3A4 | |
| Hydrochloric Acid SCHEMBL5520488 | 0.85 | CDK4 (0.59) | CYP1A2CLK4CASP1CASP7CYP3A4 | |
| SCHEMBL3971064 | 0.83 | CDK4 (0.54) | CDK4CCND1CDK2CCNE1CCNE2 | |
| SCHEMBL5634391 | 0.81 | CDK2 (0.78) | CYP1A2CLK4CASP1CASP7CYP3A4 | |
| SCHEMBL6945124 | 0.81 | CDK4 (0.70) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL6944074 | 0.80 | CDK4 (0.72) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL5634313 | 0.80 | CYP1A2 (0.68) | CYP1A2CLK4CASP1CASP7CYP3A4 | |
| SCHEMBL5520815 | 0.80 | CDK4 (0.77) | CYP1A2CLK4CASP1CASP7CYP3A4 | |
| SCHEMBL5519294 | 0.80 | CDK4 (0.77) | CYP1A2CLK4CASP1CASP7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169778-B2 | Pteridinones as kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-01-30 | — | — | US | claimed |
| EP-1409487-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-21 | — | — | EP | claimed |
| US-20030130286-A1 | Pteridinones as kinase inhibitors | DENNY WILLIAM ALEXANDER (NZ) | 2003-07-10 | — | — | US | claimed |
| WO-2001019825-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-03-22 | — | — | WO | claimed |
| US-20070049600-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY | 2007-03-01 | — | — | US | disclosed |
| US-20070049600-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY | 2007-03-01 | — | — | US | disclosed |
| US-7169778-B2 | Pteridinones as kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169778-B2 | Pteridinones as kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130286-A1 | Pteridinones as kinase inhibitors | CCNI, CCNK, CDK2 | CYP1A2 1680/4885CLK4 375/4885CASP1 3610/4885 |
| US-20070049600-A1 | PTERIDINONES AS KINASE INHIBITORS | CCNI, CCNK, CDK2 | CYP1A2 2294/4885CLK4 361/4885CASP1 3761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.