Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 0.69 |
| ▸ | HTR2A | P28223 | 13/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 9/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255569 | 0.93 | HTR2C (0.76) | HTR2CHTR2AHTR2BDRD2MAPK1 | |
| SCHEMBL5636247 | 0.93 | HTR2C (0.76) | HTR2CHTR2AHTR2BDRD2MAPK1 | |
| SCHEMBL15307683 | 0.91 | HTR2C (0.69) | HTR2CHTR2AHTR2BDRD2AHR | |
| SCHEMBL5637994 | 0.88 | HTR2C (0.54) | HTR2CHTR2AHTR2BDRD2 | |
| Hydrochloric Acid SCHEMBL5637637 | 0.87 | HTR2C (0.67) | HTR2CHTR2AHTR2BDRD2MAPK1 | |
| SCHEMBL5636191 | 0.85 | HTR2C (0.66) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL5637189 | 0.84 | HTR2C (0.64) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL5637715 | 0.84 | HTR2C (0.64) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL5637598 | 0.84 | HTR2C (0.69) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL5636301 | 0.83 | HTR2C (0.62) | HTR2CHTR2AHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |