Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.58 |
| ▸ | BRAF | P15056 | 9/20 | 0.58 |
| ▸ | RET | P07949 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | CDK8 | P49336 | 2/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | MUSK | O15146 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29664907 | 0.93 | RAF1 (0.68) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL1412957 | 0.93 | RAF1 (0.68) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL30448225 | 0.88 | BRAF (0.54) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL2559430 | 0.84 | BRAF (0.72) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL28415556 | 0.82 | BRAF (0.63) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL31255796 | 0.82 | BRAF (0.58) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL5635314 | 0.81 | RAF1 (0.86) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL6051249 | 0.81 | BRAF (0.69) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL28896139 | 0.79 | BRAF (0.49) | RAF1BRAFRETKDRCDK8 | |
| SCHEMBL14422917 | 0.78 | RET (0.69) | RAF1BRAFRETKDRCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641759-B1 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |
| US-20070213374-A1 | Malonamide Derivatives | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| EP-1641759-A2 | MALONAMIDE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005005389-A2 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213374-A1 | Malonamide Derivatives | RAF1, BRAF, ARAF | RAF1 1/4885BRAF 2/4885RET 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.