Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.68 |
| ▸ | BRAF | P15056 | 7/20 | 0.68 |
| ▸ | KDR | P35968 | 7/20 | 0.68 |
| ▸ | RET | P07949 | 3/20 | 0.68 |
| ▸ | CDK8 | P49336 | 3/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | HTR1A | P08908 | 2/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.68 |
| ▸ | KIT | P10721 | 2/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.68 |
| ▸ | FLT1 | P17948 | 2/20 | 0.68 |
| ▸ | MAOA | P21397 | 2/20 | 0.68 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.68 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.68 |
| ▸ | TTK | P33981 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412957 | 1.00 | RAF1 (0.68) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL5635463 | 0.93 | RAF1 (0.58) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL2559430 | 0.90 | BRAF (0.72) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL30448225 | 0.89 | BRAF (0.54) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL6051249 | 0.88 | BRAF (0.69) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL28415556 | 0.84 | BRAF (0.63) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL31255796 | 0.84 | BRAF (0.58) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL16620824 | 0.83 | KDR (0.65) | RAF1BRAFKDRRETCDK8 | |
| SCHEMBL28896139 | 0.81 | BRAF (0.49) | RAF1BRAFKDRRETCDK8 | |
| Sorafenib SCHEMBL14739751 | 0.81 | RAF1 (1.00) | RAF1BRAFKDRRETCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004183-B | Sorafenib antitumor inhibition auxiliary compound and composition and application thereof | 中山大学附属第三医院（中山大学肝脏病医院） | 2023-03-14 | — | — | CN | disclosed |
| CN-114728000-A | Novel pharmaceutical combination for the treatment of cancer | 荷兰癌症研究所-安东尼·范·雷文虎克医院基金会 | 2022-07-08 | — | — | CN | disclosed |