Sugi Predict

Sugi Predict / Compounds / SCHEMBL563572

SCHEMBL563572

SCHEMBL563572

Br/C=C/c1cnc2ccccc2c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDGFRB P09619 4/20 0.73
▸ PDGFRA P16234 4/20 0.73
▸ RAB9A P51151 3/20 0.63
▸ KDM4E B2RXH2 2/20 0.56
▸ KMT2A Q03164 2/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ CYP1A2 P05177 2/20 0.55
▸ ALDH1A1 P00352 7/20 0.47
▸ GAA P10253 2/20 0.47
▸ MAPT P10636 2/20 0.47
▸ LMNA P02545 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ MEN1 O00255 1/20 0.46
▸ NPC1 O15118 1/20 0.46
▸ BIRC5 O15392 1/20 0.45
▸ MGAM O43451 1/20 0.44
▸ ADORA2A P29274 1/20 0.43
▸ CYP2A6 P11509 1/20 0.42
▸ HPGD P15428 2/20 0.41
▸ GLA P06280 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL563573 1.00 PDGFRB (0.73) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL28287604 0.86 PDGFRB (0.65) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL3164867 0.85 PDGFRB (1.00) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL3164863 0.85 PDGFRB (1.00) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL7117727 0.84 PDGFRB (0.67) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL3915003 0.84 PDGFRB (0.67) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL4872097 0.84 PDGFRB (0.67) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL3914996 0.84 PDGFRB (0.67) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL7668269 0.83 PDGFRB (0.71) PDGFRBPDGFRARAB9AKDM4EKMT2A
SCHEMBL372292 0.83 PDGFRB (0.71) PDGFRBPDGFRARAB9AKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140135485-A1 6-11 BICYCLIC KETOLIDE DERIVATIVES ENANTA PHARMACEUTICALS, INC. (US) 2014-05-15 — — US disclosed
US-20120035352-A1 6-11 Bicyclic Ketolide Derivatives OR YAT SUN (US) 2012-02-09 — — US disclosed
EP-1506214-B1 6-11 BICYCLIC KETOLIDE DERIVATIVES ENANTA PHARM INC (US) 2010-01-20 — — EP disclosed
US-20090324577-A1 6-11 Bicyclic Ketolide Derivatives OR YAT SUN 2009-12-31 — — US disclosed
US-20070244160-A1 6-11 Bicyclic Ketolide Derivatives OR YAT SUN 2007-10-18 — — US disclosed
US-7273853-B2 6-11 bicyclic ketolide derivatives ENANTA PHARMACEUTICALS, INC. (US) 2007-09-25 — — US disclosed
US-7189704-B2 6-11 bicyclic ketolide derivatives ENANTA PHARMACEUTICALS, INC. (US) 2007-03-13 — — US disclosed
US-7064110-B2 6-11 bicycle ketolide derivatives ENANTA PHARMACEUTICALS, INC. (US) 2006-06-20 — — US disclosed
US-20050282758-A1 6-11 Bicyclic ketolide derivatives NIU DEQIANG 2005-12-22 — — US disclosed
US-20050159370-A1 6-11 Bicyclic ketolide derivatives ENANTA PHARMACEUTICALS, INC. (US) 2005-07-21 — — US disclosed
WO-2005061526-A1 6-11 BICYCLIC KETOLIDE DRIVATIVES ENANTA PHARMACEUTICALS, INC. (US) 2005-07-07 — — WO disclosed
WO-2005061525-A1 6-11 BICYCLIC KETOLIDE DERIVATIVES ENANTA PHARMACEUTICALS, INC. (US) 2005-07-07 — — WO disclosed
US-6878691-B2 6-11 bicyclic ketolide derivatives ENANTA PHARMACEUTICALS, INC. (US) 2005-04-12 — — US disclosed
US-20050037982-A1 6-11 Bicyclic ketolide derivatives ENANTA PHARMACEUTICALS, INC. 2005-02-17 — — US disclosed
EP-1506214-A1 6-11 BICYCLIC KETOLIDE DERIVATIVES Enanta Pharmaceuticals, Inc. (US) 2005-02-16 — — EP disclosed
WO-2004087728-A2 6,11-3C-BICYCLIC 9A-AZALIDE DERIVATIVES ENANTA PHARMACEUTICALS, INC. (US) 2004-10-14 — — WO disclosed
US-20040157787-A1 6-11 Bicyclic ketolide derivatives ENANTA PHARMACEUTICALS, INC. 2004-08-12 — — US disclosed
WO-2003097659-A1 6-11 BICYCLIC KETOLIDE DERIVATIVES ENANTA PHARMACEUTICALS, INC. (US) 2003-11-27 — — WO disclosed
US-6645941-B1 Bactericides, antiprotozoa agents ENANTA PHARMACEUTICALS, INC. 2003-11-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140135485-A1 6-11 BICYCLIC KETOLIDE DERIVATIVES AKR1C2, AKR1C3, AKR1C1 PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885
US-20120035352-A1 6-11 Bicyclic Ketolide Derivatives AKR1C2, AKR1C3, AKR1C1 PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885
US-20050282758-A1 6-11 Bicyclic ketolide derivatives AKR1C2, AKR1C3, AKR1C1 PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885
US-20070244160-A1 6-11 Bicyclic Ketolide Derivatives AKR1C2, AKR1C3, AKR1C1 PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885
US-20090324577-A1 6-11 Bicyclic Ketolide Derivatives AKR1C2, AKR1C3, AKR1C1 PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885
US-20050037982-A1 6-11 Bicyclic ketolide derivatives AKR1C2, AKR1C3, AKR1C1 PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885
US-20040157787-A1 6-11 Bicyclic ketolide derivatives AKR1C2, AKR1C3, AKR1C1 PDGFRB 4171/4885PDGFRA 3954/4885RAB9A 2499/4885
US-20050159370-A1 6-11 Bicyclic ketolide derivatives AKR1C2, AKR1C3, AKR1C1 PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.