Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.73 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.73 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL563572 | 1.00 | PDGFRB (0.73) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL28287604 | 0.86 | PDGFRB (0.65) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL3164867 | 0.85 | PDGFRB (1.00) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL3164863 | 0.85 | PDGFRB (1.00) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL7117727 | 0.84 | PDGFRB (0.67) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL3915003 | 0.84 | PDGFRB (0.67) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL4872097 | 0.84 | PDGFRB (0.67) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL3914996 | 0.84 | PDGFRB (0.67) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL7668269 | 0.83 | PDGFRB (0.71) | PDGFRBPDGFRARAB9AKDM4EKMT2A | |
| SCHEMBL372292 | 0.83 | PDGFRB (0.71) | PDGFRBPDGFRARAB9AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140135485-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-20120035352-A1 | 6-11 Bicyclic Ketolide Derivatives | OR YAT SUN (US) | 2012-02-09 | — | — | US | disclosed |
| CN-102127133-A | 6-11 bicyclic ketolide derivatives | ENANTA PHARM INC | 2011-07-20 | — | — | CN | disclosed |
| CN-101955508-A | 6-11 dicyclo ketone macrolide derivatives | ENANTA PHARM INC | 2011-01-26 | — | — | CN | disclosed |
| EP-1506214-B1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARM INC (US) | 2010-01-20 | — | — | EP | disclosed |
| US-20090324577-A1 | 6-11 Bicyclic Ketolide Derivatives | OR YAT SUN | 2009-12-31 | — | — | US | disclosed |
| US-20070244160-A1 | 6-11 Bicyclic Ketolide Derivatives | OR YAT SUN | 2007-10-18 | — | — | US | disclosed |
| US-7273853-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2007-09-25 | — | — | US | disclosed |
| US-7189704-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| CN-1914221-A | 6-11 bicyclic ketomacrolide derivatives | ENANTA PHARM INC (US) | 2007-02-14 | — | — | CN | disclosed |
| WO-2005061526-A1 | 6-11 BICYCLIC KETOLIDE DRIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061525-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| CN-1633444-A | 6-11 bicyclic ketomacrolide derivatives | ENANTA PHARM INC (US) | 2005-06-29 | — | — | CN | disclosed |
| US-6878691-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2005-04-12 | — | — | US | disclosed |
| US-20050037982-A1 | 6-11 Bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. | 2005-02-17 | — | — | US | disclosed |
| EP-1506214-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | Enanta Pharmaceuticals, Inc. (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2004087728-A2 | 6,11-3C-BICYCLIC 9A-AZALIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| US-20040157787-A1 | 6-11 Bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. | 2004-08-12 | — | — | US | disclosed |
| WO-2003097659-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |
| US-6645941-B1 | Bactericides, antiprotozoa agents | ENANTA PHARMACEUTICALS, INC. | 2003-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135485-A1 | 6-11 BICYCLIC KETOLIDE DERIVATIVES | AKR1C2, AKR1C3, AKR1C1 | PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885 |
| US-20120035352-A1 | 6-11 Bicyclic Ketolide Derivatives | AKR1C2, AKR1C3, AKR1C1 | PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885 |
| US-20070244160-A1 | 6-11 Bicyclic Ketolide Derivatives | AKR1C2, AKR1C3, AKR1C1 | PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885 |
| US-20090324577-A1 | 6-11 Bicyclic Ketolide Derivatives | AKR1C2, AKR1C3, AKR1C1 | PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885 |
| US-20050037982-A1 | 6-11 Bicyclic ketolide derivatives | AKR1C2, AKR1C3, AKR1C1 | PDGFRB 4248/4885PDGFRA 4028/4885RAB9A 2564/4885 |
| US-20040157787-A1 | 6-11 Bicyclic ketolide derivatives | AKR1C2, AKR1C3, AKR1C1 | PDGFRB 4171/4885PDGFRA 3954/4885RAB9A 2499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.