Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 19/20 | 1.00 |
| ▸ | MMP2 | P08253 | 16/20 | 1.00 |
| ▸ | MMP8 | P22894 | 1/20 | 0.74 |
| ▸ | MMP12 | P39900 | 1/20 | 0.74 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.74 |
| ▸ | MMP1 | P03956 | 1/20 | 0.73 |
| ▸ | MMP9 | P14780 | 2/20 | 0.68 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177413 | 1.00 | ADAM10 (1.00) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2174794 | 1.00 | ADAM10 (1.00) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2174785 | 1.00 | ADAM10 (1.00) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2175622 | 0.98 | ADAM10 (0.96) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2175626 | 0.98 | ADAM10 (0.96) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2174668 | 0.95 | ADAM10 (0.98) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2174680 | 0.95 | ADAM10 (0.98) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172912 | 0.94 | ADAM10 (0.95) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172920 | 0.94 | ADAM10 (0.95) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL3457411 | 0.87 | ADAM10 (0.84) | ADAM10ERBB2MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509075-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | claimed |