Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 0.40 |
| ▸ | DRD2 | P14416 | 17/20 | 0.40 |
| ▸ | HTR2A | P28223 | 17/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5637094 | 0.91 | DRD2 (0.42) | HTR2CDRD2HTR2A | |
| SCHEMBL5637105 | 0.89 | DRD2 (0.42) | HTR2CDRD2HTR2A | |
| SCHEMBL5636365 | 0.89 | HTR2C (0.38) | HTR2CDRD2HTR2AEEDRBBP4 | |
| SCHEMBL5636364 | 0.88 | DRD2 (0.42) | HTR2CDRD2HTR2A | |
| SCHEMBL5638305 | 0.88 | DRD2 (0.38) | HTR2CDRD2HTR2A | |
| SCHEMBL5636086 | 0.87 | USP30 (0.45) | HTR2CDRD2HTR2AJAK2JAK1 | |
| SCHEMBL5637203 | 0.85 | HTR2A (0.45) | HTR2CDRD2HTR2A | |
| SCHEMBL5637177 | 0.85 | HTR2C (0.42) | HTR2CDRD2HTR2A | |
| SCHEMBL5638532 | 0.85 | HTR2C (0.39) | HTR2CDRD2HTR2A | |
| SCHEMBL5637898 | 0.85 | HTR2C (0.43) | HTR2CDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |