Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.73 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532443 | 0.84 | HSD11B1 (1.00) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4534774 | 0.80 | HSD11B1 (0.92) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4535544 | 0.74 | HSD11B1 (0.82) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4352915 | 0.72 | HSD11B1 (0.77) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4352914 | 0.72 | HSD11B1 (0.77) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4533979 | 0.70 | HSD11B1 (1.00) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4524293 | 0.70 | HSD11B1 (0.74) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4349858 | 0.70 | HSD11B1 (1.00) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL4534996 | 0.68 | HSD11B1 (1.00) | HSD11B1NR1I2 | |
| SCHEMBL4533088 | 0.67 | HSD11B1 (0.77) | HSD11B1HSD11B2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532122-B1 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK SHARP & DOHME (US) | 2011-12-14 | — | — | EP | disclosed |
| EP-1532122-B1 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK SHARP & DOHME (US) | 2011-12-14 | — | — | EP | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-6730690-B2 | DELAYING THE ONSET OR REDUCING THE RISK OF DEVELOPING ATHEROSCLEROSIS IN A HUMAN PATIENT COMPRISING ADMINISTERING TO SAID PATIENT AN EFFECTIVE AMOUNT OF A COMPOUND OF INVENTION AND AN HMG-COA REDUCTASE INHIBITOR | MERCK & CO., INC. | 2004-05-04 | — | — | US | disclosed |