Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5638490 | 0.90 | HTR2C (0.56) | HTR2CHTR2AHTR2BTLR8TLR7 | |
| SCHEMBL5637170 | 0.88 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| SCHEMBL5636468 | 0.87 | HTR2C (0.75) | HTR2CHTR2AHTR2B | |
| SCHEMBL5637201 | 0.87 | HTR2C (0.56) | HTR2CHTR2AHTR2BTLR8TLR7 | |
| SCHEMBL5635413 | 0.85 | HTR2C (0.60) | HTR2CHTR2AHTR2BTLR8TLR7 | |
| SCHEMBL15800579 | 0.85 | HTR2C (0.62) | HTR2CHTR2AHTR2B | |
| SCHEMBL5635151 | 0.85 | HTR2A (0.62) | HTR2CHTR2AHTR2B | |
| SCHEMBL17039082 | 0.85 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| SCHEMBL5636371 | 0.85 | HTR2C (0.62) | HTR2CHTR2AHTR2B | |
| SCHEMBL5413927 | 0.85 | HTR2C (0.76) | HTR2CHTR2AHTR2BTLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |