Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | HTR2B | P41595 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.30 |
| ▸ | CTSV | O60911 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635170 | 0.95 | HTR2C (0.46) | HTR2CHTR2AHTR2BACP1KCNH2 | |
| SCHEMBL5636451 | 0.88 | HTR2C (0.51) | HTR2CHTR2AHTR2BKMT2AALDH1A1 | |
| SCHEMBL5636401 | 0.85 | HTR2C (0.45) | HTR2CHTR2AHTR2BKCNH2HTR6 | |
| SCHEMBL5410687 | 0.85 | HTR2C (0.66) | HTR2CHTR2AHTR2BKMT2AMEN1 | |
| SCHEMBL5410691 | 0.85 | HTR2C (0.66) | HTR2CHTR2AHTR2BKMT2AMEN1 | |
| SCHEMBL5637734 | 0.85 | HTR2C (0.54) | HTR2CHTR2AHTR2BKMT2AMEN1 | |
| SCHEMBL5636687 | 0.84 | HTR2C (0.56) | HTR2CHTR2AHTR2BHTR6 | |
| SCHEMBL5405461 | 0.84 | HTR2C (0.62) | HTR2CHTR2AHTR2BKMT2AMEN1 | |
| SCHEMBL5637170 | 0.83 | HTR2C (0.54) | HTR2CHTR2AHTR2BKCNH2CYP2D6 | |
| SCHEMBL5636424 | 0.83 | HTR2C (0.47) | HTR2CHTR2AHTR2BACP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |