Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.55 |
| ▸ | GNRHR | P30968 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5640777 | 0.89 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12GNRHR | |
| SCHEMBL5637540 | 0.87 | MAPK14 (0.63) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL5638989 | 0.86 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12GNRHR | |
| SCHEMBL5639957 | 0.86 | MAPK14 (0.56) | MAPK14MAPK11MAPK13MAPK12GNRHR | |
| SCHEMBL5641118 | 0.82 | MAPK14 (0.58) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL5639854 | 0.82 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL5637592 | 0.81 | MAPK14 (0.71) | MAPK14MAPK11MAPK13MAPK12ALDH1A1 | |
| SCHEMBL5639812 | 0.79 | MAPK14 (0.54) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL5640778 | 0.76 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12ALDH1A1 | |
| SCHEMBL5639954 | 0.75 | MAPK14 (0.68) | MAPK14MAPK11MAPK13MAPK12TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253191-B2 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2007-08-07 | — | — | US | disclosed |
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-20040116416-A1 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2004-06-17 | — | — | US | disclosed |
| EP-1362045-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066458-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |