Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | GNRHR | P30968 | 1/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5640778 | 0.90 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5637541 | 0.88 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5638985 | 0.86 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5639961 | 0.85 | ALOX5 (0.44) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5641122 | 0.84 | ALOX5 (0.44) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5639815 | 0.80 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5637592 | 0.76 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5640777 | 0.75 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5639239 | 0.74 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5637540 | 0.73 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253191-B2 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2007-08-07 | — | — | US | disclosed |
| US-20040116416-A1 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2004-06-17 | — | — | US | disclosed |