Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.53 |
| ▸ | PPARG | P37231 | 5/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 2/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089700 | 0.93 | PPARA (0.47) | PPARAPPARGACECTSSSYK | |
| SCHEMBL8893121 | 0.85 | PPARA (0.54) | PPARAPPARGACECTSSSYK | |
| SCHEMBL8893110 | 0.85 | PPARA (0.54) | PPARAPPARGACECTSSSYK | |
| SCHEMBL13574478 | 0.83 | MDM4 (0.46) | PPARAPPARGACEMAPT | |
| SCHEMBL12856084 | 0.82 | ACE (0.54) | ACECTSLKLK5 | |
| SCHEMBL22469444 | 0.82 | MAPT (0.39) | PPARAPPARGCTSSSYKCTSL | |
| SCHEMBL22469361 | 0.82 | MAPT (0.39) | PPARAPPARGCTSSSYKCTSL | |
| SCHEMBL22469446 | 0.82 | MAPT (0.39) | PPARAPPARGCTSSSYKCTSL | |
| SCHEMBL22469359 | 0.82 | MAPT (0.39) | PPARAPPARGCTSSSYKCTSL | |
| SCHEMBL22469357 | 0.82 | MAPT (0.39) | PPARAPPARGCTSSSYKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110150835-A1 | Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease | SCHERING CORPORATION | 2011-06-23 | — | — | US | disclosed |
| EP-1192136-B1 | OLIGOMERS AND POLYMERS OF CYCLIC IMINO CARBOXYLIC ACIDS | WISCONSIN ALUMNI RES FOUND (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-1664092-B1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORP (US) | 2011-02-02 | — | — | EP | disclosed |
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| WO-2009058856-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |
| US-7304165-B2 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304165-B2 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304165-B2 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-6914048-B2 | Method for delivery of molecules to intracellular targets | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2005-07-05 | — | — | US | disclosed |
| WO-2005030796-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORPORATION (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20040152133-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | GELLMAN SAMUEL H (US) | 2004-08-05 | — | — | US | disclosed |
| US-6727368-B1 | PYRROLIDINE-3-CARBOXYLIC ACID MONOMERS; POLYLACTAMS; COMBINATORIAL LIBRARIES | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-04-27 | — | — | US | disclosed |
| US-6710186-B2 | CONFORMATIONALLY-RESTRICTED; ANALOGOUS TO POLY(PROLINE) II HELICAL STRUCTURE | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-03-23 | — | — | US | disclosed |
| WO-2003024477-A1 | METHOD FOR DELIVERY OF MOLECULES TO INTRACELLULAR TARGETS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2003-03-27 | — | — | WO | disclosed |
| EP-1192136-A2 | OLIGOMERS AND POLYMERS OF CYCLIC IMINO CARBOXYLIC ACIDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2002-04-03 | — | — | EP | disclosed |
| US-20020032334-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2002-03-14 | — | — | US | disclosed |
| WO-2000076974-A2 | OLIGOMERS AND POLYMERS OF CYCLIC IMINO CARBOXYLIC ACIDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032334-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | PCNA, PAICS, INHA | PPARA 2627/4885PPARG 3602/4885ACE 3022/4885 |
| US-20040152133-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | PCNA, PAICS, INHA | PPARA 2627/4885PPARG 3602/4885ACE 3022/4885 |
| US-20110150835-A1 | Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease | TMPRSS15, SPINT2, HPN | PPARA 3540/4885PPARG 4210/4885ACE 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.