Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 19/20 | 0.69 |
| ▸ | MMP2 | P08253 | 17/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.69 |
| ▸ | MMP9 | P14780 | 11/20 | 0.69 |
| ▸ | MMP3 | P08254 | 7/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5640396 | 1.00 | ADAM10 (0.69) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5640390 | 1.00 | ADAM10 (0.69) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2174452 | 1.00 | ADAM10 (0.69) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL3456793 | 0.90 | ADAM10 (0.60) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5636205 | 0.90 | ADAM10 (0.68) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2176913 | 0.90 | ADAM10 (0.68) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5636195 | 0.90 | ADAM10 (0.68) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5636184 | 0.90 | ADAM10 (0.68) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2174878 | 0.89 | ADAM10 (0.70) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2177293 | 0.87 | ADAM10 (0.68) | ADAM10MMP2ERBB2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509075-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | claimed |