Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.71 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29336072 | 0.87 | LMNA (0.72) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL30802565 | 0.87 | LMNA (0.72) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL5642964 | 0.86 | LMNA (0.53) | LMNAMAPK1NLRP1EPHX2NR1H4 | |
| SCHEMBL5642926 | 0.85 | LMNA (0.75) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL29335953 | 0.85 | LMNA (0.71) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL5646507 | 0.85 | LMNA (0.70) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL20269915 | 0.83 | LMNA (0.67) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL29336076 | 0.83 | LMNA (0.76) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL29336034 | 0.83 | LMNA (0.67) | LMNAMAPK1NLRP1EPHX2TSHR | |
| SCHEMBL21490251 | 0.81 | LMNA (0.68) | LMNAMAPK1NLRP1EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |