Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564702 | 1.00 | NPC1 (0.52) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL697981 | 0.95 | ALDH1A1 (0.47) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL883239 | 0.92 | NPC1 (0.59) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL883027 | 0.92 | HTR2C (0.46) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL10182646 | 0.86 | USP30 (0.58) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL564703 | 0.85 | ALDH1A1 (0.44) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL14845515 | 0.85 | NPC1 (0.60) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL11910976 | 0.85 | NPC1 (0.60) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL882753 | 0.85 | ALDH1A1 (0.49) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL23247917 | 0.84 | SMN1; SMN2 (0.53) | NPC1ALDH1A1LMNANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436036-B2 | Diaryl ethers | JANSSEN R&D IRELAND (IE) | 2013-05-07 | — | — | US | disclosed |
| US-20120034678-A1 | Diaryl Ethers | JANSSEN SCIENCES IRELAND UC (IE) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120034678-A1 | Diaryl Ethers | SLC10A1, CYP2F1, UGT1A1 | NPC1 62/4885ALDH1A1 325/4885LMNA 2568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.