Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 3/20 | 0.42 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792508 | 0.79 | MEN1 (0.59) | MEN1KMT2AKDM4EALOX5APFEN1 | |
| SCHEMBL5391050 | 0.78 | MAOB (0.57) | ALKBH1MAOBRAB9A | |
| SCHEMBL29975453 | 0.76 | GRM5 (0.48) | ALKBH1ALDH1A1MAOBIDO1 | |
| SCHEMBL16792648 | 0.75 | KMT2A (0.77) | MEN1KMT2AKDM4EALOX5APFEN1 | |
| SCHEMBL5650346 | 0.75 | IDO1 (0.49) | MEN1KMT2AKDM4EMAOBIDO1 | |
| SCHEMBL5653373 | 0.74 | ALOX5AP (0.39) | ALOX5APFEN1ALKBH1ALDH1A1MAOB | |
| SCHEMBL4415791 | 0.73 | MAOB (0.63) | MEN1KMT2AKDM4EMAOBIDO1 | |
| SCHEMBL4639016 | 0.72 | MAOB (0.54) | KDM4EALKBH1ALDH1A1MAOBDCPS | |
| SCHEMBL9424821 | 0.72 | KDM4E (0.46) | MEN1KMT2AKDM4EALOX5APFEN1 | |
| SCHEMBL3365264 | 0.71 | MEN1 (0.60) | MEN1KMT2AKDM4EMAOBIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |