Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | MGMT | P16455 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650853 | 0.75 | RAB9A (0.41) | ALDH1A1L3MBTL1LMNAPTGER1 | |
| SCHEMBL5650015 | 0.74 | MEN1 (0.51) | ALOX5APFEN1ALKBH1MAOBALDH1A1 | |
| SCHEMBL5651640 | 0.74 | MAOB (0.49) | MPOMGMTMAOBMAPTLMNA | |
| SCHEMBL5648620 | 0.74 | L3MBTL1 (0.47) | MPOMGMTTLR8MAOBFFAR1 | |
| SCHEMBL21572248 | 0.73 | MEN1 (0.56) | MAPTALDH1A1 | |
| SCHEMBL5655538 | 0.71 | KDM4E (0.54) | MPOMAOBFFAR1MAPTDHFR | |
| SCHEMBL4639016 | 0.71 | MAOB (0.54) | ALKBH1MAOBMAPTALDH1A1DCPS | |
| SCHEMBL5652395 | 0.71 | PIN1 (0.45) | MPOTLR8MAOBFFAR1MAPT | |
| SCHEMBL7539477 | 0.70 | SYK (0.49) | MGMTTLR8TLR7L3MBTL1 | |
| SCHEMBL5391050 | 0.70 | MAOB (0.57) | ALKBH1MAOBMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |