Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403859 | 0.72 | CSK (0.34) | — | |
| SCHEMBL4868126 | 0.68 | KDM1A (0.35) | ALDH1A1LMNA | |
| SCHEMBL7529131 | 0.68 | GAA (0.59) | EPHX2L3MBTL1CYP3A4CYP2C19KMT2A | |
| SCHEMBL4878751 | 0.68 | KDM1A (0.35) | NPC1RAB9A | |
| SCHEMBL14617667 | 0.68 | SMN1; SMN2 (0.81) | SMN1; SMN2L3MBTL1CYP2C19KMT2AGAA | |
| SCHEMBL25412009 | 0.68 | GAA (0.63) | SMN1; SMN2CYP2C19KMT2AGAAALDH1A1 | |
| SCHEMBL9509533 | 0.67 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1KMT2AGAAALDH1A1 | |
| SCHEMBL25410244 | 0.67 | GAA (0.61) | SMN1; SMN2CYP2C19KMT2AGAAALDH1A1 | |
| SCHEMBL12765264 | 0.67 | GAA (0.61) | SMN1; SMN2EPHX2L3MBTL1CYP3A4CYP2C19 | |
| SCHEMBL9080 | 0.66 | GAA (0.66) | SMN1; SMN2EPHX2L3MBTL1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208166-A1 | Tao Kinase Modulators And Method Of Use | EXELIXIS, INC. (US) | 2007-09-06 | — | — | US | claimed |
| US-20070208166-A1 | Tao Kinase Modulators And Method Of Use | EXELIXIS, INC. (US) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208166-A1 | Tao Kinase Modulators And Method Of Use | TAOK1, TAOK3, MAP3K6 | SMN1; SMN2 4552/4885EPHX2 3128/4885L3MBTL1 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.