Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 12/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5968557 | 0.93 | F2 (0.45) | F2CYP3A4PRSS1P2RX7DPP4 | |
| SCHEMBL5652332 | 0.92 | F2 (0.51) | F2CYP3A4P2RX7 | |
| SCHEMBL5648618 | 0.90 | P2RX7 (0.50) | F2CYP3A4P2RX7 | |
| Hydrochloric Acid SCHEMBL5649636 | 0.89 | F2 (0.61) | F2CYP3A4PRSS1P2RX7 | |
| SCHEMBL27649111 | 0.89 | F2 (0.45) | F2KCNH2TDP1 | |
| SCHEMBL27669312 | 0.88 | CYP3A4 (0.44) | F2CYP3A4PRSS1P2RX7DPP4 | |
| SCHEMBL5647748 | 0.88 | F2 (0.47) | F2CYP3A4P2RX7 | |
| SCHEMBL5650336 | 0.87 | F2 (0.40) | F2CYP3A4PRSS1P2RX7DPP4 | |
| SCHEMBL27669314 | 0.86 | P2RX7 (0.40) | F2CYP3A4PRSS1P2RX7DPP4 | |
| SCHEMBL5650742 | 0.84 | F2 (0.51) | F2CYP3A4PRSS1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161643-A1 | Pyridin-2-one compounds useful as inhibitors of thrombin | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
| EP-1713774-A1 | NEW PYRIDIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075424-A1 | NEW PYRIDIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161643-A1 | Pyridin-2-one compounds useful as inhibitors of thrombin | PLG, F2, PLAT | F2 2/4885CYP3A4 267/4885PRSS1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.