Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651294 | 0.98 | HDAC3 (0.50) | SMN1; SMN2HDAC3HDAC1HDAC2LMNA | |
| SCHEMBL11002950 | 0.80 | HDAC3 (0.49) | SMN1; SMN2HDAC3HDAC1HDAC2LMNA | |
| SCHEMBL31241104 | 0.79 | ADORA1 (0.47) | SMN1; SMN2LMNANPSR1ADORA1ADORA3 | |
| SCHEMBL3056248 | 0.79 | NPC1 (0.55) | SMN1; SMN2HDAC3HDAC1HDAC2PTPN1 | |
| SCHEMBL5653762 | 0.78 | NAMPT (0.51) | SMN1; SMN2ADORA1ADORA3ADORA2APTPN1 | |
| SCHEMBL5654440 | 0.76 | NAMPT (0.50) | SMN1; SMN2ADORA1PTPN1PTPN2MEN1 | |
| SCHEMBL31240994 | 0.75 | ABL1 (0.51) | SMN1; SMN2LMNAADORA1ADORA3ADORA2A | |
| SCHEMBL15743965 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNANPSR1ADORA1ADORA3 | |
| SCHEMBL29874618 | 0.72 | NPC1 (0.54) | SMN1; SMN2RAB9AKMT2ATSHRHPGD | |
| SCHEMBL28847350 | 0.72 | NPC1 (0.54) | SMN1; SMN2RAB9AKMT2ATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |