Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654440 | 0.98 | NAMPT (0.50) | NAMPTSMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL13702044 | 0.81 | SMN1; SMN2 (0.64) | NAMPTSMN1; SMN2ATMALDH1A1KDM4E | |
| SCHEMBL5650768 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2AADORA1ADORA3 | |
| SCHEMBL5651294 | 0.76 | HDAC3 (0.50) | SMN1; SMN2MEN1KMT2AADORA1ADORA3 | |
| SCHEMBL17963904 | 0.75 | GAA (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4439106 | 0.75 | NAMPT (0.88) | NAMPTSMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL31241104 | 0.74 | ADORA1 (0.47) | SMN1; SMN2KMT2ARXFP1ADORA1ADORA3 | |
| SCHEMBL27947891 | 0.74 | MAPT (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL28649332 | 0.74 | NAMPT (0.85) | NAMPTSMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL944219 | 0.74 | CYP1A2 (0.63) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |