Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.71 |
| ▸ | KDR | P35968 | 5/20 | 0.70 |
| ▸ | EGFR | P00533 | 9/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10152557 | 0.93 | AURKA (0.69) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5651656 | 0.92 | EGFR (0.65) | AURKAKDREGFRAURKBMAPK14 | |
| Hydrochloric Acid SCHEMBL2063014 | 0.92 | AURKA (0.69) | AURKAKDREGFRAURKBMAPK14 | |
| Hydrochloric Acid SCHEMBL5652341 | 0.92 | AURKA (0.69) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5022265 | 0.91 | KDR (0.70) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5016618 | 0.90 | AURKA (0.69) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5023489 | 0.89 | AURKA (0.78) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5091097 | 0.88 | AURKA (0.70) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5655354 | 0.88 | EGFR (0.65) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5653702 | 0.87 | AURKA (0.71) | AURKAKDREGFRAURKBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |