Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.71 |
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | EGFR | P00533 | 5/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651175 | 0.91 | AURKA (0.60) | AURKAKDREGFRAURKBEPHA2 | |
| SCHEMBL5652597 | 0.91 | AURKA (0.69) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5650776 | 0.87 | AURKA (0.71) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5023489 | 0.87 | AURKA (0.78) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5091097 | 0.86 | AURKA (0.70) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5016550 | 0.84 | KDR (0.74) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5016557 | 0.84 | AURKA (0.74) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5016571 | 0.83 | AURKA (0.66) | AURKAKDREGFRAURKBMAPK14 | |
| SCHEMBL5091131 | 0.80 | AURKA (0.69) | AURKAKDREGFRAURKBFBP1 | |
| SCHEMBL5025360 | 0.79 | AURKA (0.67) | AURKAKDREGFRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |