Sugi Predict

Sugi Predict / Compounds / SCHEMBL565162

SCHEMBL565162

SCHEMBL565162

CC(C)CN(Cc1cc(Br)c2c(c1)OCCCO2)C(=O)C1CN(Cc2ccccc2)CCO1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.65
▸ GRN P28799 1/20 0.38
▸ SORT1 Q99523 1/20 0.38
▸ KDM4E B2RXH2 3/20 0.36
▸ ACHE P22303 1/20 0.36
▸ ALDH1A1 P00352 4/20 0.34
▸ GRIN2B Q13224 2/20 0.34
▸ GAA P10253 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ POLB P06746 2/20 0.34
▸ PKM P14618 1/20 0.33
▸ DRD4 P21917 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ CHRM5 P08912 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL565513 0.92 PROKR2 (0.76) PROKR2GRNSORT1KDM4EACHE
SCHEMBL565322 0.91 PROKR2 (0.72) PROKR2GRNSORT1KDM4EACHE
SCHEMBL565068 0.88 PROKR2 (0.63) PROKR2KDM4EACHEALDH1A1GAA
SCHEMBL3517508 0.88 PROKR2 (0.63) PROKR2GRNSORT1KDM4EACHE
SCHEMBL387975 0.88 PROKR2 (0.63) PROKR2GRNSORT1KDM4EACHE
SCHEMBL3516623 0.88 PROKR2 (0.63) PROKR2GRNSORT1KDM4EACHE
SCHEMBL565491 0.88 PROKR2 (0.54) PROKR2KDM4EACHESMN1; SMN2POLB
SCHEMBL3518564 0.86 PROKR2 (0.61) PROKR2GRNSORT1KDM4EACHE
SCHEMBL10107537 0.85 PROKR2 (0.73) PROKR2GRNSORT1KDM4EALDH1A1
SCHEMBL3518382 0.85 PROKR2 (0.61) PROKR2GRNSORT1KDM4EACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof PROKR2, PROKR1, GIPR PROKR2 1/4885GRN 548/4885SORT1 1202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.