Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PRNP | P04156 | 6/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14315170 | 0.84 | ALDH1A1 (0.70) | LMNAALDH1A1L3MBTL1HSD17B10HTT | |
| SCHEMBL10521309 | 0.77 | SMN1; SMN2 (0.57) | ALDH1A1L3MBTL1TP53CYP2C9SMN1; SMN2 | |
| SCHEMBL4126057 | 0.76 | HSD17B10 (0.69) | LMNAALDH1A1L3MBTL1HSD17B10HTT | |
| Hydrochloric Acid SCHEMBL10755615 | 0.76 | SMN1; SMN2 (0.56) | ALDH1A1L3MBTL1TP53CYP2C9SMN1; SMN2 | |
| SCHEMBL10761269 | 0.76 | SMN1; SMN2 (0.56) | LMNAALDH1A1L3MBTL1TP53CYP1A2 | |
| SCHEMBL14398958 | 0.76 | HTT (0.59) | LMNAALDH1A1L3MBTL1HSD17B10HTT | |
| SCHEMBL10704988 | 0.76 | SMN1; SMN2 (0.56) | ALDH1A1L3MBTL1HTTTP53KDM4E | |
| SCHEMBL10708467 | 0.75 | SMN1; SMN2 (0.52) | ALDH1A1L3MBTL1TP53CYP2C9SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10709402 | 0.75 | SMN1; SMN2 (0.55) | ALDH1A1L3MBTL1HTTTP53KDM4E | |
| Hydrochloric Acid SCHEMBL10760840 | 0.74 | SMN1; SMN2 (0.51) | ALDH1A1L3MBTL1TP53CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176215-B2 | Bicyclic oxopyridine and oxopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2007-02-13 | — | — | US | disclosed |
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | UCB PHARMA S.A. (BE) | 2004-12-16 | — | — | US | disclosed |
| EP-1438313-A1 | BICYCLIC OXOPYRIDINE AND OXOPYRIMIDINE DERIVATIVES | Celltech R & D Limited (GB) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003033502-A1 | BICYCLIC OXOPYRIDINE AND OXOPYRIMIDINE DERIVATIVES | CELLTECH R & D LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | MAPK1, ALK, NAT1 | LMNA 1417/4885ALDH1A1 1498/4885L3MBTL1 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.