Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 7/20 | 0.66 |
| ▸ | AURKA | O14965 | 4/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.64 |
| ▸ | EGFR | P00533 | 6/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527097 | 0.90 | AURKB (0.82) | AURKBAURKAMAPK14EGFRKDR | |
| SCHEMBL10152557 | 0.85 | AURKA (0.69) | AURKBAURKAMAPK14EGFRKDR | |
| SCHEMBL5651730 | 0.85 | AURKB (0.81) | AURKBAURKAMAPK14EGFRKDR | |
| Hydrochloric Acid SCHEMBL2063014 | 0.84 | AURKA (0.69) | AURKBAURKAMAPK14EGFRKDR | |
| Hydrochloric Acid SCHEMBL5652341 | 0.84 | AURKA (0.69) | AURKBAURKAMAPK14EGFRKDR | |
| Hydrochloric Acid SCHEMBL2463942 | 0.84 | AURKB (0.80) | AURKBAURKAMAPK14EGFRKDR | |
| SCHEMBL5650637 | 0.83 | AURKA (0.72) | AURKBAURKAMAPK14EGFRKDR | |
| SCHEMBL5649428 | 0.83 | AURKA (0.75) | AURKBAURKAMAPK14EGFRKDR | |
| SCHEMBL5655354 | 0.82 | EGFR (0.65) | AURKBAURKAMAPK14EGFRKDR | |
| SCHEMBL5652597 | 0.81 | AURKA (0.69) | AURKBAURKAMAPK14EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |