Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.69 |
| ▸ | EGFR | P00533 | 7/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | LTK | P29376 | 1/20 | 0.57 |
| ▸ | TTK | P33981 | 1/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651175 | 0.92 | AURKA (0.60) | AURKAAURKBEGFRKDR | |
| SCHEMBL5653702 | 0.91 | AURKA (0.71) | AURKAAURKBEGFRMAPK14KDR | |
| SCHEMBL10152557 | 0.87 | AURKA (0.69) | AURKAAURKBEGFRMAPK14IRAK4 | |
| Hydrochloric Acid SCHEMBL5652341 | 0.86 | AURKA (0.69) | AURKAAURKBEGFRMAPK14IRAK4 | |
| Hydrochloric Acid SCHEMBL2063014 | 0.86 | AURKA (0.69) | AURKAAURKBEGFRMAPK14IRAK4 | |
| SCHEMBL5650637 | 0.85 | AURKA (0.72) | AURKAAURKBEGFRMAPK14IRAK4 | |
| SCHEMBL5649428 | 0.85 | AURKA (0.75) | AURKAAURKBEGFRMAPK14IRAK4 | |
| SCHEMBL5652138 | 0.85 | AURKA (0.68) | AURKAAURKBEGFRMAPK14IRAK4 | |
| SCHEMBL5652140 | 0.85 | AURKA (0.68) | AURKAAURKBEGFRMAPK14IRAK4 | |
| SCHEMBL5651730 | 0.83 | AURKB (0.81) | AURKAAURKBEGFRMAPK14IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |