Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.83 |
| ▸ | RET | P07949 | 5/20 | 0.83 |
| ▸ | KIF5B | P33176 | 5/20 | 0.83 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.73 |
| ▸ | FLT1 | P17948 | 1/20 | 0.73 |
| ▸ | EGFR | P00533 | 7/20 | 0.71 |
| ▸ | ILK | Q13418 | 1/20 | 0.68 |
| ▸ | FBP1 | P09467 | 1/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 2/20 | 0.64 |
| ▸ | KDM1A | O60341 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7865973 | 0.99 | KDR (0.82) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL5651286 | 0.91 | KDR (1.00) | KDRRETKIF5BFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7859467 | 0.90 | KDR (0.98) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL7864670 | 0.86 | KDR (0.80) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL7451147 | 0.86 | KDR (0.73) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL1467795 | 0.85 | EGFR (0.66) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL7454466 | 0.85 | KDR (0.78) | KDRRETKIF5BFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7712346 | 0.85 | KDR (0.71) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL7455454 | 0.84 | EGFR (0.79) | KDRRETKIF5BFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7455631 | 0.84 | KDR (0.77) | KDRRETKIF5BFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| WO-2005115145-A2 | QUINONE SUBSTITUTED QUINAZOLINE AND QUINOLINE KINASE INHIBITORS | WYETH (US) | 2005-12-08 | — | — | WO | disclosed |
| EP-0885198-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| EP-0885198-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032856-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | KDR, FLT1, FLT4 | KDR 1/4885RET 81/4885KIF5B 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.