Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.82 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 14/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.67 |
| ▸ | FLT1 | P17948 | 5/20 | 0.67 |
| ▸ | FLT4 | P35916 | 5/20 | 0.67 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653766 | 0.90 | KDR (1.00) | KDRSRCEGFRFGFR1FLT1 | |
| SCHEMBL5651242 | 0.88 | KDR (0.89) | KDRSRCEGFRFGFR1FLT1 | |
| SCHEMBL5654784 | 0.85 | KDR (1.00) | KDRSRCEGFRFGFR1FLT1 | |
| SCHEMBL5653077 | 0.85 | KDR (0.85) | KDR | |
| SCHEMBL5648069 | 0.84 | KDR (1.00) | KDREGFR | |
| SCHEMBL5648809 | 0.83 | KDR (0.82) | KDREGFR | |
| SCHEMBL5649175 | 0.83 | KDR (0.79) | KDRSRCEGFRFGFR1FLT1 | |
| SCHEMBL5652926 | 0.82 | KDR (0.71) | KDRSRCEGFR | |
| SCHEMBL5654084 | 0.82 | KDR (0.76) | KDRSRCEGFR | |
| SCHEMBL3193284 | 0.81 | KDR (0.79) | KDRSRCEGFRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | KDR, FLT1, FLT4 | KDR 1/4885SRC 960/4885EGFR 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.