Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29457401 | 0.83 | GABRA5 (0.52) | GABRA5PKM | |
| SCHEMBL510168 | 0.83 | GABRA5 (0.52) | GABRA5PKM | |
| SCHEMBL29987845 | 0.81 | CHRNA7 (0.47) | HTR1ADRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL4234692 | 0.81 | CHRNA7 (0.47) | HTR1ADRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL12016548 | 0.81 | MEN1 (0.50) | HTR1ADRD2HSD17B10MEN1KMT2A | |
| SCHEMBL4060132 | 0.80 | MAPK1 (0.56) | HTR1ADRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL31240666 | 0.79 | HSD17B10 (0.46) | HTR1ADRD2HSD17B10GABRA5MEN1 | |
| SCHEMBL31360482 | 0.78 | CYP2D6 (0.53) | HTR1ADRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL12014977 | 0.77 | FFAR1 (0.44) | HTR1ADRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL22792043 | 0.76 | IKBKB (0.45) | HTR1ADRD2HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |