Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888632 | 1.00 | PIM2 (0.45) | PIM2BACE1BACE2DHFRPIK3CD | |
| SCHEMBL4024230 | 0.87 | PIM2 (0.47) | PIM2BACE1BACE2DHFRPIK3CD | |
| SCHEMBL28799914 | 0.84 | PIM2 (0.45) | PIM2BACE1BACE2DHFRPIK3CD | |
| SCHEMBL30018047 | 0.84 | PIM2 (0.47) | PIM2BACE1BACE2DHFRPIK3CD | |
| SCHEMBL29793885 | 0.81 | CTSL (0.48) | BACE1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL5216832 | 0.81 | CTSL (0.48) | BACE1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL5249260 | 0.81 | CTSL (0.48) | BACE1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL5218298 | 0.79 | MKNK1 (0.56) | BACE1CYP19A1CYP2A6 | |
| SCHEMBL5848606 | 0.79 | MKNK1 (0.56) | BACE1CYP19A1CYP2A6 | |
| SCHEMBL21290740 | 0.77 | PIM2 (0.55) | PIM2BACE1BACE2DHFRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091202-B2 | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-15 | — | — | US | disclosed |
| US-20060063790-A1 | 4-Arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063790-A1 | 4-Arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | KCNQ2, KCNQ1, KCNQ4 | PIM2 1511/4885BACE1 588/4885BACE2 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.