Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 7/20 | 0.61 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653881 | 0.88 | ALDH1A1 (0.56) | GBA1GLAKDM4EMAPTALDH1A1 | |
| SCHEMBL14349132 | 0.85 | TACR1 (0.55) | GBA1GLAKDM4EMAPTALDH1A1 | |
| SCHEMBL4659314 | 0.81 | ALDH1A1 (0.58) | GLAKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL14349125 | 0.81 | MCHR1 (0.49) | GBA1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL4659313 | 0.81 | ALDH1A1 (0.53) | GBA1GLAKDM4EMAPTALDH1A1 | |
| SCHEMBL4658305 | 0.79 | ALDH1A1 (0.53) | KDM4EMAPTALDH1A1HPGDNPC1 | |
| SCHEMBL14349128 | 0.78 | MCHR1 (0.50) | GBA1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL4658238 | 0.77 | KDM4E (0.47) | GBA1GLAKDM4EMAPTALDH1A1 | |
| SCHEMBL14349133 | 0.77 | MCHR1 (0.47) | GBA1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL14349130 | 0.77 | MCHR1 (0.46) | KDM4EMAPTALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | GBA1 1864/4885GLA 3784/4885KDM4E 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.