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Sugi Predict / Compounds / SCHEMBL565433

SCHEMBL565433

SCHEMBL565433

CC(C)CN(Cc1cc(F)c2c(c1)OCCCO2)C(=O)C1CN(Cc2ccccc2)CCN1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.55
▸ F2 P00734 1/20 0.35
▸ KDM4E B2RXH2 4/20 0.35
▸ ACHE P22303 1/20 0.35
▸ MLNR O43193 2/20 0.35
▸ GAA P10253 1/20 0.34
▸ TP53 P04637 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ BACE1 P56817 1/20 0.34
▸ CYP2D6 P10635 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ UBE2M P61081 1/20 0.33
▸ DCUN1D1 Q96GG9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL564249 0.92 PROKR2 (0.58) PROKR2F2KDM4EACHEGAA
SCHEMBL565249 0.87 PROKR2 (0.63) PROKR2KDM4EACHEGAALMNA
SCHEMBL565322 0.86 PROKR2 (0.72) PROKR2KDM4EACHETP53LMNA
SCHEMBL565334 0.86 PROKR2 (0.63) PROKR2KDM4ELMNARAB9A
SCHEMBL565426 0.79 PROKR2 (0.73) PROKR2KDM4EACHE
SCHEMBL565136 0.79 PROKR2 (0.73) PROKR2KDM4EACHE
SCHEMBL564878 0.78 PROKR2 (0.63) PROKR2KDM4EACHECYP2D6
SCHEMBL565186 0.78 PROKR2 (0.64) PROKR2KDM4ERAB9A
SCHEMBL565330 0.78 PROKR2 (0.73) PROKR2KDM4ELMNACYP2D6RAB9A
SCHEMBL565513 0.78 PROKR2 (0.76) PROKR2KDM4EACHECYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
WO-2010077976-A2 PROKINETICIN RECEPTOR ANTAGONISTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof PROKR2, PROKR1, GIPR PROKR2 1/4885F2 1649/4885KDM4E 4874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.